RESEARCH INTERESTS
TIFR is a premier science research institution in India. Having started in TIFR, Mumbai, I am currently in TIFR Hyderabad which is the newest centre of TIFR. TIFR-H officially started in 2011 and we have a thriving academic community in our centre working on various aspects of science.
Our group is involved in research in SOLID-STATE NMR. Our research comprises theory, numerical simulations, and experiments. We focus on methods development and biomolecular applications. In methods, we design pulse schemes to improve sensitivity and resolution of solid-state NMR spectra of spin-1/2 and half-integer spin quadrupolar systems. We have been working on schemes for distance measurement between spin-1/2 nuclei.
On the applications side, we have been studying Aβ42 and Aβ40 fibril systems. The goal here is to elucidate the aggregation and fibrilisation pathways, structural reasons for toxicity, and modulating the peptides for therapeutic purposes. We are currently actively looking at the structural details of low-weight oligomers of these fibril peptides.