3082
mvig @ tifrh . res . in
FReTB, PI-210
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Research Overview
Our lab studies the origin and outcome of tyrosine kinase- and G-protein coupled receptor-induced intracellular calcium ion flux using T lymphocytes as a model system. Calcium ions are important signalling intermediates and CRAC channels constitute a primary route of calcium entry in almost all cell types. Mutations in molecular components of CRAC channels can cause severe immunodeficiencies in humans and mice. We aim to identify the key molecular players and pathways that directly regulate store-operated calcium entry, study the underlying regulatory mechanisms, and decipher the consequences of their deletion or mutation using a combination of molecular, genetic, biochemical, and imaging approaches. The proposed studies can potentially provide insights into life-threatening immunodeficiencies, autoimmunity, and cancer.