Research

Our lab studies the mechanism of chromosomal replication in mammalian cells and processes that are responsible for maintaining genomic integrity. We specifically explore the dynamic and systematic changes that occur on the replication fork in response to various cellular and environment cues. Further, we strive to understand the pre-, during, and post-replication measures that ensure fidelity during genome duplication.

Broadly, we are exploring the following key questions:

1. How replisome complex is specifically organized in response to various genomic contexts?
2. What are the regulatory mechanisms that decide to skip lesions and select error-prone polymerases during replication?
3. Role of licensing, activation, and firing components of mammalian replication and pathophysiology of Meier-Gorlin syndrome.
4. Mechanism of DNA-protein crosslinks (DPC) repair.