Dr. Kaustubh R. Mote

Dr. Mote uses solid state NMR spectroscopy to understand the active transport of metabolites across membranes at the molecular level. Current work in the lab focuses on two fronts: (1) Development of techniques for oriented and magic angle spinning NMR techniques for characterization of biomolecules and (2) Understanding the molecular basis of pyruvate transport across the inner mitochondrial membrane through the Mitochondrial Pyruvate Carrier Complex. The long term goal of the lab is to leverage improved techniques in solid state NMR to determine an atomistic picture of metabolite transport across biological membranes. This is expected to yield insights into metabolic processes in healthy and diseased cells.