People

Dr. Kanchan Garai

Principal Investigator

Email: kanchan at tifrh dot res dot in

Phone: +91 40 20203076

Academic qualifications

• Reader, TIFR Hyderabad, India
• Post Doctorate Research Scientist, Washington University School of medicine, St. Louis, USA
• Ph.D., Tata Institute of Fundamental Research, Mumbai

Deepa Saraswati

Scientific Officer

Sourav Das Adhikari

B.Sc St.Paul’s CM College

M.Sc, Presidency University

My interest is to unravel the complex mechanism of protein aggregation  using different biophysical techniques including single-molecular techniques, such as TIRF-M, FCS, and STORM.

Sudip Pal

B.Sc, Chemistry, St. Paul’s Cathedral Mission College, University of Calcutta

M.Sc in Chemistry, University of Calcutta

My research aims to unravel the difference(s) in dynamics, stability, solvent exposure, and the presence of intermediate state(s) among the isoforms of Apolipoprotein E. We aim to elucidate the subtle differences in the structural dynamics by employing Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) as a tool. These experiments may shed light on the underlying mechanisms associated with the pathological functions attributed to ApoE4.

Vinoth Kumar V

B.Sc, Dept. of Zoology, Loyola College, Chennai

My work focuses on understanding the structural differences between ApoE isoforms and their effects on neurodegeneration using Drosophila as a model (in collaboration with Dr. Manish Jaiswal). Outside science, my interests are running, swimming, and fishkeeping.

Mahaprasad Soumitri Ranjan Sahu

Integrated MSc. In chemistry,  NISER, Bhubaneswar, India

Tau is an intrinsically disordered protein responsible for various neurodegenerative diseases such as Alzheimer’s disease, Frontotemporal dementia with Parkinsonism, Pick’s disease, etc. The protein is able to follow different paths to produce neurofibrillary tangles which are the main cause of tauopathy and subsequent neuronal death. These paths are fibrillation, fragmentation in the presence of polyanions such as RNAs, heparin, etc., and coacervates formation through liquid-liquid phase separation (LLPS). We are interested to observe biophysical studies such as nucleation, molecular rate constant inside and outside of the dense phase Tau LLPS in real time using Total internal reflection microscopy (TIRFM), confocal microscopy etc.

Dr. Aslam Uddin

Research Associate

Past Members